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MHC class 2 transactivator C2TA (CIITA, MHC2TA)
Function:
- essential for transcriptional activity of the HLA class 2 promoter; activation is via the proximal promoter
- forms transcriptional complex with RFX
- no DNA binding of in vitro translated CIITA
- may act in coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class 2 promoter, to elements of the transcription machinery, or both
- may activate HLA class 2 transcription by modifying proteins that bind to the MHC class 2 promoter
- interacts with ZXDA & ZXDC
Structure:
- contains 4 LRR repeats (leucine-rich repeats)
- contains 1 NACHT domain
Compartment: nucleus
Pathology:
- defects in CIITA are a cause of bare lymphocyte syndrome-2
General
transcription factor (TF)
Properties
SIZE: entity length = 1130 aa
MW = 123 kD
COMPARTMENT: cell nucleus
MOTIF: acidic region {52-137}
MOTIF: acidic residue (SEVERAL)
leucine-rich repeat
SITE: 98-121
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 214-238
MOTIF: leucine residue (SEVERAL)
NACHT domain
NAME: NACHT domain
SITE: 414-724
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 420-427
leucine-rich repeat
SITE: 1014-1037
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 1071-1094
MOTIF: leucine residue (SEVERAL)
Database Correlations
OMIM correlations
MORBIDMAP 600005
UniProt P33076
PFAM correlations
Kegg hsa:4261
References
- UniProt :accession P33076
- CIITAbase; Note: CIITA mutation db
http://bioinf.uta.fi/CIITAbase/
- Atlas of genetics & cytogenetics in oncology & haematology
http://atlasgeneticsoncology.org/genes/MHC2TAID260.html