MHC class II regulatory factor RFX1; transcription factor RFX1; regulatory factor X 1; RFX; enhancer factor C; EF-C (RFX1)

Function: - regulatory factor essential for MHC class 2 gene expression - binds to the X boxes of MHC class 2 genes - also binds to an inverted repeat (ENH1) required for hepatitis B virus gene expression & to the most upstream element (alpha) of the RPL30 promoter - binds DNA as a homodimer Structure: belongs to the RFX family Compartment: nucleus

General

DNA-binding protein phosphoprotein transcription factor (TF)

Properties

SIZE: entity length = 979 aa MW = 105 kD COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S120} glycine-rich region {381-411} DNA-binding motif SITE: 441-512 Necessary for dimerization {744-979} MOTIF: acidic region {920-936} MOTIF: acidic residue (SEVERAL)

Database Correlations

OMIM correlations UniProt P22670 PFAM correlations Kegg hsa:5989

References

UniProt :accession P22670