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methyprylon (Noludar)
Tradename: Noludar. DEA-controlled substance: class 3.
Dosage: 200-400 mg PO QHS.
Tabs: 200 & 300 mg.
Pharmacokinetics:
1) metabolized in liver to multiple products, some with pharmacologic activity
2) t1/2 of 4 hours, prolonged to 50 hours with acute overdose
Adverse effects:
1) drowsiness
2) ataxia
3) acute overdose
a) coma
b) hypotension
c) shock
Laboratory:
1) specimen: serum
2) methods: GLC, color
Interactions
drug adverse effects (more general classes)
General
sedative/hypnotic (tranquilizer)
Properties
MISC-INFO: elimination route LIVER
1/2life 4 HOURS
therapeutic-range 8-10 UG/ML
toxic-range >50 UG/ML
elimination by hemodialysis -
hemoperfusion +
peritoneal dialysis +/-
Database Correlations
PUBCHEM cid=4162
References
- The Pharmacological Basis of Therapeutics, 9th ed.
Gilman et al, eds. Permagon Press/McGraw Hill, 1996
- Clinical Guide to Laboratory Tests, NW Tietz (ed) 3rd ed,
WB Saunders, Philadelpha 1995