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C-4 methylsterol oxidase; methylsterol monooxygenase (SC4MOL, DESP4, ERG25, MSMO1)
Function:
- enzyme of cholesterol biosynthesis
- steroid biosynthesis; zymosterol biosynthesis
- zymosterol from lanosterol: step 3/6
Cofactor: iron (probable)
Structure:
- 3 transmembrane domains
- the histidine box domains may contain the active site &/or be involved in metal ion binding
- belongs to the sterol desaturase family
Compartment:
- endoplasmic reticulum membrane
- multi-pass membrane protein (probable)
Interactions
molecular events
Related
methyl sterol oxidase gene
General
oxidoreductase
Properties
SIZE: entity length = 293 aa
MW = 35 kD
COMPARTMENT: endoplasmic reticulum
MOTIF: transmembrane domain {55-75}
transmembrane domain {100-120}
Histidine box-1 {157-161}
Histidine box-2 {170-174}
transmembrane domain {199-219}
Histidine box-3 {249-255}
Database Correlations
OMIM 607545
UniProt Q15800
Pfam PF04116
Entrez Gene 6307
Kegg hsa:6307
ENZYME 1.14.13.72
References
- UniProt :accession Q15800
- Janowskii et al,
The hypocholesterolemic agent LY295427 reverses suppression of
sterol regulatory element-binding protein processing mediated
by oxysterols.
J Biol Chem 276:45408, 2001
PMID: 11577112