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methohexital (Brevital)

Indications: - induction & maintenance of general anesthesia for short procedures Contraindications: porphyria Caution: 1) hepatic insufficiency 2) asthma 3) cardiovascular instability Dosage: 1) adults: a) induction: 1-2 mg/kg IV (50-120 mg) b) maintenance: 20-40 mg every 4-7 min 2) children: a) preop: 5-10 mg/kg IM, 20-35 mg/kg rectal b) induction: 1-2 mg/kg Powder for injection: 500 mg. Pharmacokinetics: duration of action: 5 minutes. Adverse effects: 1) common (> 10%) - pain on IM injection 2) less common (1-10%) - cramping, diarrhea, rectal bleeding 3) uncommon (< 1%) - radial nerve palsy, hemolytic anemia, thrombophlebitis, hypotension, peripheral vascular collapse, seizures, tremor, headache, nausea/vomiting, involuntary muscle movement, twitching, rigidity, apnea, respiratory depression, laryngospasm, hiccups, coughing Drug interactions: CNS depressants

General

dissociative anesthetic

Properties

MISC-INFO: elimination route LIVER pregnancy-category B safety in lactation ?

Database Correlations

PUBCHEM correlations

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  2. Kaiser Permanente Northern California Regional Drug Formulary, 1998