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methionine-R-sulfoxide reductase B3, mitochondrial (MsrB3, MSRB3)
Function:
- catalyzes the reduction of free & protein-bound methionine sulfoxide to methionine
L-methionine + oxidized thioredoxin L-methionine R-oxide + reduced thioredoxin
Cofactor: binds 1 Zn+2 per subunit
Structure:
- monomer
- belongs to the msrB Met sulfoxide reductase family
- has a signal peptide
Compartment:
- isoform 1: mitochondrion
- isoform 2: endoplasmic reticulum
Alternative splicing: named isoforms=2
Expression:
- detected in eye lens, colon, bone marrow, cerebellum, small intestine, heart, kidney & spinal cord
General
mitochondrial protein
oxidoreductase
Properties
SIZE: entity length = 185 aa
MW = 20 kD
COMPARTMENT: mitochondria
endoplasmic reticulum
MOTIF: Zn+2-binding site
SITE: 79-79
Zn+2-binding site
SITE: 82-82
Zn+2-binding site
SITE: 128-128
Zn+2-binding site
SITE: 131-131
cysteine residue {C151}
Database Correlations
UniProt Q8IXL7
Pfam PF01641
Kegg hsa:2538
References
UniProt :accession Q8IXL7