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methionine aminopeptidase 2 (metAP 2, peptidase M 2, initiation factor 2 associated 67 kD glycoprotein, P67)
Function:
- removes the amino-terminal Met from nascent proteins
- release of N-terminal amino acids, preferentially Met, from peptides & arylamides
Cofactor: binds 2 Co+2 per subunit (putative)
Structure: belongs to the peptidase M24C family
Related
ceramide
General
glycoprotein
methionyl aminopeptidase
Properties
SIZE: entity length = 478 aa
MW = 53 kD
MOTIF: lysine-rich region {36-46}
MOTIF: lysine residue (SEVERAL)
acidic region {82-93}
MOTIF: acidic residue (SEVERAL)
lysine-rich region {98-106}
MOTIF: lysine residue (SEVERAL)
histidine residue {H231}
Database Correlations
OMIM 601870
UniProt P50579
ENZYME 3.4.11.18
References
UniProt :accession P50579