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metastasis-associated protein MTA3 (MTA3, KIAA1266)
Function:
- role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription (histone deacetylase dependent), & thus regulation of E-cadherin levels
- component of the nucleosome-remodeling & histone-deacetylase multiprotein complex (NuRD complex)
Structure:
- contains 1 BAH domain
- contains 1 ELM2 domain
- contains 1 GATA-type Zn+2 finger
- contains 1 SANT domain
Compartment: nucleus
Alternative splicing: named isoforms=2
Expression:
- expressed in epithelial cells
- no expression in nonepithelial cells
- induced by estrogen
Related
histone deacetylase
metastasis
General
nuclear protein
zinc finger protein
Properties
SIZE: MW = 68 kD
entity length = 594 aa
COMPARTMENT: cell nucleus
CELL: epithelial cell
MOTIF: BAH {1-147}
ELM2 {148-209}
SANT {267-316}
Zn finger GATA-type
SITE: 379-406
EFFECTOR-BOUND: Zn+2
Database Correlations
OMIM 609050
UniProt Q9BTC8
PFAM correlations
Entrez Gene 57504
Kegg hsa:57504
References
UniProt :accession Q9BTC8