Search
metastasis-associated protein MTA2; metastasis-associated 1-like 1; MTA1-L1 protein; p53 target protein in deacetylase complex (MTA2, MTA1L1, PID)
Function:
- may be involved in the regulation of gene expression as repressor & activator
- repression might be related to covalent modification of histone proteins
- component of the nucleosome-remodeling & histone-deacetylase multiprotein complex (NuRD complex)
- interacts with HDAC7, p53/TP53, MINT & MBD3 (putative)
Structure:
- contains 1 BAH domain
- contains 1 ELM2 domain
- contains 1 GATA-type Zn+2 finger
- contains 1 SANT domain
Compartment: nucleus (putative)
Expression: widely expressed
Related
histone deacetylase
metastasis
General
nuclear protein
phosphoprotein
zinc finger protein
Properties
SIZE: entity length = 668 aa
MW = 75 kD
COMPARTMENT: cell nucleus
MOTIF: BAH {1-144}
MOTIF: Ser phosphorylation site {S57}
ELM2 {145-256}
SANT {263-315}
Zn finger GATA-type
SITE: 367-394
EFFECTOR-BOUND: Zn+2
Ser phosphorylation site {S433}
Ser phosphorylation site {S435}
Thr phosphorylation site {T505}
Thr phosphorylation site {T534}
Thr phosphorylation site {T540}
Database Correlations
OMIM 603947
UniProt O94776
PFAM correlations
Entrez Gene 9219
Kegg hsa:9219
References
UniProt :accession O94776
Component-of
nucleosome remodeling & histone deacetylation (NuRD) complex