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metanephrines in 24 hour urine
Indications:
- screening test of choice for pheochromocytoma
Normal range:
- total < 900 ug/24 hours
- metanephrine 40-300 ug/24 hours
- normetanephrine 60-600 ug/24 hours
Increases:
- catecholamine-secreting neurochromaffin tumors
- pheochromocytoma
- paraganglioma
- neuroblastome
- pharmaceutical agents:
a) in vivo effects
- nitroglycerin, phenothiazines
b) chemical interferences
- vitamin B (high doses), erythromycin, hydralazine, levodopa, methenamine hippurate, methenamine mandelate, methyldopa, nicotinic acid, quinine, quinidine, salicylate, tetracyclines
c) false positives for pheochromcytoma with [5]
- acetaminophen
- prochlorperazine
- phenoxybenzamine
- antipsychotics
- buspirone
- MAO inhibitors
- tricyclic antidepressants
- amphetamines
- cocaine
- caffeine
- levodopa
- pseudoephedrine
- reserpine
- clonidine withdrawal
- ethanol withdrawal
- illicit drugs
Decreases:
- pharmaceutical agents:
- in vivo effects
- MAO inhibitors
Interferences:
1) sympathomimetics
2) tricyclic antidepressants
3) labetalol [1]
Related
metanephrine
pheochromocytoma; paroxysmal hypertension; adrenal medullary paraganglioma; chromoffinoma
Specific
metanephrine in 24 hour urine
normetanephrine in 24 hour urine
General
metanephrines in urine
24 hour urine
References
- Mayo Internal Medicine Board Review, 1998-99, Prakash UBS (ed)
Lippincott-Raven, Philadelphia, 1998, pg 483
- Clinical Diagnosis & Management by Laboratory Methods,
19th edition, J.B. Henry (ed), W.B. Saunders Co.,
Philadelphia, PA. 1996, pg 12
- Clinical Guide to Laboratory Tests, 4th edition, HB Wu ed,
WB Saunders, Philadelphia, 2006
- Panel of 12 tests
Laboratory Test Directory ARUP: 80436
- Medical Knowledge Self Assessment Program (MKSAP) 17,
American College of Physicians, Philadelphia 2015
Component-of
hypertension panel