metal transporter CNNM3 (cyclin-M3, ancient conserved domain-containing protein 3, CNNM3, ACDP3)

Function: probable metal transporter (putative) Structure: - belongs to the ACDP family - contains 1 CBS domain Compartment: cell membrane; Multi-pass membrane protein Alternative splicing: named isoforms=3 Expression: - widely expressed - expressed at higher level in heart & spleen Note: - shares weak sequence similarity with the cyclin family, explaining its namel however, it has no cyclin-like function in vivo

General

cyclin M glycoprotein membrane protein

Properties

SIZE: entity length = 707 aa MW = 76 kD COMPARTMENT: cellular membrane MOTIF: transmembrane domain {11-27} N-glycosylation site {N73} ubiquitination site (destruction box, D-box) SITE: N-TERMINAL FOR-BINDING-OF: ubiquitin transmembrane domain {193-213} transmembrane domain {221-241} transmembrane domain {261-281} PEST region cyclin box FOR-BINDING-OF: cyclin-dependent kinase CBS {337-445}

Database Correlations

OMIM 607804 UniProt Q8NE01 PFAM correlations Entrez Gene 26505

References

UniProt :accession Q8NE01