Search
metalloreductase STEAP4; six-transmembrane epithelial antigen of prostate 4; SixTransMembrane protein of prostate 2; tumor necrosis factor; alpha-induced protein 9 (STEAP4, STAMP2, TNFAIP9)
Function:
- metalloreductase that has the ability to reduce both Fe+3 to Fe+2 & Cu+2 to Cu+
- uses NAD+ as acceptor
Cofactor: FAD (putative)
Structure:
- belongs to the STEAP family
- contains 1 ferric oxidoreductase domain
Compartment: Golgi membrane
Alternative splicing: named isoforms=2
Expression:
- ubiquitous
- highly expressed in placenta, lung, heart & prostate
- detected at lower levels in liver, skeletal muscle, pancreas, testis & small intestine
- up-regulated by androgens, including testosterone & dihydrotestosterone
General
flavoprotein
metalloprotein
oxidoreductase
metalloreductase STEAP (six-transmembrane epithelial antigen of prostate, STEAP)
Properties
SIZE: MW = 52 kD
entity length = 459 aa
COMPARTMENT: golgi
MOTIF: transmembrane domain {196-216}
transmembrane domain {246-266}
Ferric oxidoreductase {247-395}
MOTIF: transmembrane domain {293-313}
Iron [Fe]-binding site
SITE: 304-304
transmembrane domain {348-368}
transmembrane domain {381-401}
MOTIF: Iron [Fe]-binding site
SITE: 397-397
transmembrane domain {419-439}
Database Correlations
UniProt Q687X5
PFAM correlations
References
UniProt :accession Q687X5