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40S ribosomal protein S27; metallopan-stimulin 1; MPS-1 (RPS27, MPS1)
Function:
Cofactor: binds 1 Zn+2 per subunit (putative)
Structure: belongs to the ribosomal protein S27e family
Expression:
- expressed in a wide variety of actively proliferating cells & tumor tissues
Note:
- originally [2] thought to be a protein that could have played a role as a mediator of cellular proliferative responses to various growth factors & other environmental signals
- capable of specific binding to a cAMP response element in DNA
General
DNA-binding protein
phosphoprotein
zinc finger protein
Properties
SIZE: entity length = 84 aa
MW = 9 kD
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S11}
Ser phosphorylation site {S27}
Tyr phosphorylation site {Y31}
Zn finger C4-type
SITE: 37-59
EFFECTOR-BOUND: Zn+2
Ser phosphorylation site {S78}
Database Correlations
OMIM 603702
UniProt P42677
Pfam PF01667
Entrez Gene 6232
Kegg hsa:6232
References
- UniProt :accession P42677
- Fernandez-Pol JA et al
A growth factor-inducible gene encodes a novel nuclear protein
with zinc finger structure.
J Biol Chem. 1993 Oct 5;268(28):21198-204.
PMID: 8407955