Search
Metabotropic glutamate receptor 6; mGluR6 (GRM6, GPRC1F, MGLUR6)
Function:
- receptor for glutamate
- activity is mediated by a Gi-protein
Structure: belongs to the G-protein coupled receptor 3 family
Compartment: cell membrane
Pathology:
- defects in GRM6 are the cause of congenital stationary night blindness 1B
General
glycoprotein
metabotropic glutamate receptor
Properties
SIZE: entity length = 877 aa
MW = 95 kD
COMPARTMENT: post synaptic membrane
CELL-REGION: dendrite
CELL: neuron
MOTIF: signal sequence {1-24}
exoplasmic domain {25-585}
MOTIF: N-glycosylation site {N296}
N-glycosylation site {N451}
N-glycosylation site {N479}
N-glycosylation site {N567}
transmembrane domain {586-608}
cytoplasmic loop {609-622}
transmembrane domain {623-643}
exoplasmic loop {644-654}
transmembrane domain {655-673}
cytoplasmic loop {674-697}
transmembrane domain {698-718}
exoplasmic loop {719-748}
transmembrane domain {749-770}
cytoplasmic loop {771-783}
transmembrane domain {784-806}
exoplasmic loop {807-819}
transmembrane domain {820-845}
cytoplasmic domain {846-877}
Database Correlations
OMIM correlations
MORBIDMAP 604096
UniProt O15303
PFAM correlations
Entrez Gene 2916
References
UniProt :accession O15303