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Metabotropic glutamate receptor 5; mGluR5 (GRM5, GPRC1E, MGLUR5)
Function:
- receptor for glutamate
- activity is mediated by a G-protein that activates a phosphatidylinositol-Ca+2 second messenger system & generates a Ca+2-activated chloride current
- PPXXF motif binds HOMER1, HOMER2 & HOMER3
- interacts with SIAH1, RYR1, RYR2, ITPR1, SHANK1, SHANK3 & GRASP
Structure: belongs to the G-protein coupled receptor 3 family
Compartment: cell membrane
Alternative splicing: named isoforms=2
General
glycoprotein
metabotropic glutamate receptor
Properties
SIZE: entity length = 1212 aa
MW = 132 kD
COMPARTMENT: post synaptic membrane
CELL-REGION: dendrite
CELL: neuron
MOTIF: signal sequence {1-20}
exoplasmic domain {22-579}
MOTIF: N-glycosylation site {N88}
N-glycosylation site {N210}
N-glycosylation site {N378}
N-glycosylation site {N382}
N-glycosylation site {N445}
transmembrane domain {580-602}
cytoplasmic loop {603-616}
transmembrane domain {617-637}
exoplasmic loop {638-648}
transmembrane domain {649-667}
cytoplasmic loop {668-693}
transmembrane domain {694-714}
exoplasmic loop {715-737}
MOTIF: N-glycosylation site {N734}
transmembrane domain {738-759}
cytoplasmic loop {760-772}
transmembrane domain {773-795}
exoplasmic loop {796-801}
transmembrane domain {802-827}
cytoplasmic domain {828-1212}
Database Correlations
OMIM 604102
UniProt P41594
PFAM correlations
Entrez Gene 2915
Kegg hsa:2915
References
UniProt :accession P41594