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Metabotropic glutamate receptor 3; mGluR3 (GRM3, GPRC1C, MGLUR3)
Function:
- receptor for N-acetylaspartylglutamate (NAAG)
- receptor for glutamate ?
- activity is mediated by a Gi-protein
- interacts with GRASP (putative)
Structure: belongs to the G-protein coupled receptor 3 family
Compartment: cell membrane
Pathology:
- loss of receptors or decline in function within the dorsolateral prefrontal cortex (DLPFC) may play a role in schizophrenia [2]
Pharmacology:
- experimental drug used to treat schizophrenia
Pharmacokinetics:
- LY2140023, an investigational drug used for treatment of schizophrenia, is prodrug hydrolyzed to LY404039, a metabotropic glutamate receptor agonist specific for mGluR2 & mGluR3 [2]
General
glycoprotein
metabotropic glutamate receptor
Properties
SIZE: entity length = 879 aa
MW = 99 kD
COMPARTMENT: post synaptic membrane
CELL-REGION: dendrite
CELL: neuron
MOTIF: signal sequence {1-22}
exoplasmic domain {23-576}
MOTIF: N-glycosylation site {N209}
N-glycosylation site {N292}
N-glycosylation site {N414}
N-glycosylation site {N439}
transmembrane domain {577-599}
cytoplasmic loop {600-613}
transmembrane domain {614-634}
exoplasmic loop {635-645}
transmembrane domain {646-664}
cytoplasmic loop {665-688}
transmembrane domain {689-709}
exoplasmic loop {710-734}
transmembrane domain {735-756}
cytoplasmic loop {757-769}
transmembrane domain {770-792}
exoplasmic loop {793-802}
transmembrane domain {803-828}
cytoplasmic domain {829-879}
Database Correlations
OMIM 601115
UniProt Q14832
PFAM correlations
Entrez Gene 2913
Kegg hsa:2913
References
- UniProt :accession Q14832
- Ghose S et al.
Differential expression of metabotropic glutamate receptors
2 and 3 in schizophrenia: A mechanism for antipsychotic drug
action?
Am J Psychiatry 2009 Jun 1; [e-pub ahead of print].
PMID: 19487395
http://dx.doi.org/10.1176/appi.ajp.2009.08091445