Metabotropic glutamate receptor 2; mGluR2 (GRM2, GPRC1B, MGLUR2)

Function: - receptor for glutamate - activity is mediated by a Gi-protein - may mediate suppression of neurotransmission or may play role in synaptogenesis or synaptic stabilization - interacts with GRASP (putative) Structure: belongs to the G-protein coupled receptor 3 family Compartment: cell membrane Expression: - widely expressed in different regions of the adult & fetal brain

General

glycoprotein metabotropic glutamate receptor

Properties

SIZE: entity length = 872 aa MW = 96 kD COMPARTMENT: post synaptic membrane CELL-REGION: dendrite CELL: neuron MOTIF: signal sequence {1-18} exoplasmic domain {19-567} MOTIF: N-glycosylation site {N203} N-glycosylation site {N286} N-glycosylation site {N338} N-glycosylation site {N402} N-glycosylation site {N547} transmembrane domain {568-590} cytoplasmic loop {591-604} transmembrane domain {605-625} exoplasmic loop {626-636} transmembrane domain {637-655} cytoplasmic loop {656-679} transmembrane domain {680-700} exoplasmic loop {701-725} transmembrane domain {726-747} cytoplasmic loop {748-760} transmembrane domain {761-783} exoplasmic loop {784-793} transmembrane domain {794-819} cytoplasmic domain {820-872}

Database Correlations

OMIM 604099 UniProt Q14416 PFAM correlations Entrez Gene 2912 Kegg hsa:2912

References

UniProt :accession Q14416