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Metabotropic glutamate receptor 1; mGluR1 (GRM1, GPRC1A, MGLUR1)
Function:
- receptor for glutamate
- activity is mediated by a G-protein that activates a phosphatidylinositol- Ca+2 second messenger system
- may play role in CNS action of glutamate
a) long-term potentiation in the hippocampus
b) long-term depression in the cerebellum
- interacts with SIAH1, RYR1, RYR2, ITPR1, SHANK1, SHANK3 & GRASP (putative)
Structure:
- homodimer; disulfide-linked
- PPXXF motif in proline rich region binds to EVH1 domain in HOMER1, HOMER2 & HOMER3 [2]
- belongs to the G-protein coupled receptor 3 family
Compartment: cell membrane
Alternative splicing: named isoforms=2; alpha, beta
Interactions
molecular events
General
glycoprotein
metabotropic glutamate receptor
phosphoprotein
Properties
SIZE: entity length = 1194 aa
MW = 132 kD
COMPARTMENT: post synaptic membrane
CELL-REGION: dendrite
CELL: neuron
MOTIF: signal sequence {1-18}
exoplasmic domain {19-592}
MOTIF: N-glycosylation site {N98}
cysteine residue {C140}
MODIFICATION: cysteine residue {C-INTERCHAIN}
N-glycosylation site {N223}
N-glycosylation site {N397}
N-glycosylation site {N515}
transmembrane domain {593-615}
cytoplasmic loop {616-629}
transmembrane domain {630-650}
exoplasmic loop {651-661}
transmembrane domain {662-680}
MOTIF: Tyr phosphorylation site {Y672}
cytoplasmic loop {681-706}
transmembrane domain {707-727}
exoplasmic loop {728-750}
transmembrane domain {751-772}
cytoplasmic loop {773-785}
transmembrane domain {786-808}
exoplasmic loop {809-814}
transmembrane domain {815-840}
cytoplasmic domain {841-1194}
MOTIF: proline-rich region
SITE: 1014-1035
MOTIF: proline residue (SEVERAL)
proline-rich region
SITE: 1067-1081
MOTIF: proline residue (SEVERAL)
acidic region {1095-1130}
MOTIF: acidic residue (SEVERAL)
Tyr phosphorylation site {Y1109}
Tyr phosphorylation site {Y1111}
serine-rich region {1142-1194}
MOTIF: serine residue (SEVERAL)
Database Correlations
OMIM 604473
UniProt Q13255
PFAM correlations
Entrez Gene 2911
Kegg hsa:2911
References
- UniProt :accession Q13255
- Sheng M.
Molecular organization of the postsynaptic specialization.
Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7058-61. Review.
PMID: 11416187
Component-of
molecular complex