mesoderm-specific transcript homolog protein (paternally-expressed gene 1 protein, MEST, PEG1)

Structure: - belongs to the AB hydrolase superfamily Compartment: membrane Alternative splicing: named isoforms=3 Expression: - biallelic expression is detected in blood lymphocytes - seems to imprinted in an isoform-specific manner rather than in a tissue-specific manner in lymphocytes - isoform 1 is expressed only from the paternal allele - isoform 2 is expressed from both the paternal allele & maternal allel - monoallelic expression of paternally derived allele observed in all fetal tissues examined, including brain, skeletal muscle, kidney, adrenal, tongue, heart, skin, & placenta - in 75-day fetus, expressed in the amnion, brain, heart, lung, stomach, gut, adrenal, kidney, muscle, & liver Pathology: - highly expressed in hydatidiform moles - barely expressed in dermoid cysts

General

glycoprotein membrane protein

Properties

SIZE: MW = 39 kD entity length = 335 aa COMPARTMENT: cellular membrane MOTIF: transmembrane domain {13-33} transmembrane domain {63-83} RVIALD {98-103} N-glycosylation site {N163} transmembrane domain {266-286}

Database Correlations

OMIM 601029 UniProt Q5EB52 Pfam PF00561

References

UniProt :accession Q5EB52