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melatonin receptor type 1A; mel1a melatonin receptor; mel-1A-R (MTNR1A)
Function:
- high affinity receptor for melatonin
- likely to mediate reproductive & circadian actions of melatonin
- activity is mediated by pertussis toxin sensitive Gi proteins
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane
Expression:
- expressed in hypophyseal pars tuberalis & hypothalamic suprachiasmatic nuclei (SCN)
- expressed in hippocampus
Related
melatonin
General
glycoprotein
melatonin receptor
Properties
SIZE: entity length = 350 aa
MW = 39 kD
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-29}
MOTIF: N-glycosylation site {N4}
N-glycosylation site {N10}
transmembrane domain {30-50}
cytoplasmic loop {51-63}
transmembrane domain {64-84}
exoplasmic loop {85-102}
MOTIF: cysteine residue {C100}
MODIFICATION: cysteine residue {C177}
transmembrane domain {103-123}
cytoplasmic loop {124-142}
transmembrane domain {143-163}
exoplasmic loop {164-187}
MOTIF: cysteine residue {C177}
MODIFICATION: cysteine residue {C100}
transmembrane domain {188-208}
cytoplasmic loop {209-240}
transmembrane domain {241-261}
exoplasmic loop {262-274}
transmembrane domain {275-295}
cytoplasmic domain {296-350}
Database Correlations
OMIM 600665
UniProt P48039
Pfam PF00001
Entrez Gene 4543
Kegg hsa:4543
References
- UniProt :accession P48039
- Wikipedia; melatonin receptor entry
http://en.wikipedia.org/wiki/melatonin_receptor