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CD228, melanotransferrin or melanoma-associated antigen p97
Function:
- role in iron cellular uptake
Cofactor:
- binds a single atom of iron per subuni
- may also bind Zn+2
Compartment:
- attached to the membrane by a GPI-anchor
- appears to be internalized, then recycled back to the plasma membrane
Expression:
- fetal tissues
- liver, epithelium, umbilical cord, placenta, sweat gland ducts,
- capillary endothelial cells especially in brain
Pathology:
- expressed in melanomas
- serum levels are increased in patients with Alzheimer's disease [2]
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glycoprotein
melanoma associated antigen (MAGE)
metalloprotein
plasma membrane protein
Properties
SIZE: MW = 97 kD
COMPARTMENT: plasma membrane
MOTIF: signal sequence {1-19}
consensus repeat {20-361}
MOTIF: cysteine residue {C26}
MODIFICATION: cysteine residue {C63}
cysteine residue {C36}
MODIFICATION: cysteine residue {C54}
N-glycosylation site {N38}
cysteine residue {C54}
MODIFICATION: cysteine residue {C36}
cysteine residue {C63}
MODIFICATION: cysteine residue {C26}
Iron [Fe]-binding site
SITE: 78-78
Iron [Fe]-binding site
SITE: 107-107
cysteine residue {C130}
MODIFICATION: cysteine residue {C216}
binding site
SITE: 132-132
FOR-BINDING-OF: CO3=
N-glycosylation site {N135}
binding site
SITE: 136-136
FOR-BINDING-OF: CO3=
binding site
SITE: 138-138
FOR-BINDING-OF: CO3=
binding site
SITE: 139-139
FOR-BINDING-OF: CO3=
cysteine residue {C172}
MODIFICATION: cysteine residue {C189}
cysteine residue {C186}
MODIFICATION: cysteine residue {C199}
cysteine residue {C189}
MODIFICATION: cysteine residue {C172}
cysteine residue {C199}
MODIFICATION: cysteine residue {C186}
Iron [Fe]-binding site
SITE: 210-210
cysteine residue {C216}
MODIFICATION: cysteine residue {C130}
cysteine residue {C257}
MODIFICATION: cysteine residue {C271}
cysteine residue {C271}
MODIFICATION: cysteine residue {C257}
Iron [Fe]-binding site
SITE: 279-279
consensus repeat {362-713}
MOTIF: Iron [Fe]-binding site
SITE: 421-421
Iron [Fe]-binding site
SITE: 451-451
N-glycosylation site {N515}
Iron [Fe]-binding site
SITE: 556-556
Iron [Fe]-binding site
SITE: 625-625
glycosyl phosphatidylinositol [GPI] membrane anchor {C-TERMINUS}
Database Correlations
OMIM 155750
UniProt P08582
Entrez Gene 4241
References
- UniProt :accession P08582
- Kennard ML et al
Serum levels of the iron binding protein p97 are elevated in
Alzheimer's disease.
Nature Medicine 2:1230 1996
PMID: 8898750