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melanoma-derived growth regulatory protein; melanoma inhibitory activity protein (MIA)
Function:
1) inhibits growth of melanoma cells in vitro
2) inhibits growth of other neuroectodermal tumors, including gliomas
Structure:
1) may possess 2 intramolecular disulfide bonds
2) belongs to the MIA/OTOR family
- contains 1 SH3 domain
Compartment: secreted
Pathology:
- expressed in malignant melanoma cell lines
- infrequently expressed in glioma cell lines
Laboratory:
- melanoma inhibitory activity protein in serum/plasma
Related
melanoma
melanoma inhibitory activity protein 2 (MIA2)
melanoma inhibitory activity protein 3 (protein TANGO, C219-reactive peptide, D320, MIA3, KIAA0268, UNQ6077/PRO20088)
General
secreted protein
Properties
SIZE: MW = 15 kD
entity length = 131 aa
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-24}
cysteine residue {C36}
MODIFICATION: cysteine residue {C41}
cysteine residue {C41}
MODIFICATION: cysteine residue {C36}
src homology 3 [SH3] domain
SITE: 43-113
MOTIF: cysteine residue {C59}
MODIFICATION: cysteine residue {C130}
cysteine residue {C130}
MODIFICATION: cysteine residue {C59}
Database Correlations
OMIM 601340
UniProt Q16674
Pfam PF07653
References
UniProt :accession Q16674