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melanoma-associated antigen 11; MAGE-11 antigen; cancer/testis antigen 1.11; CT1.11 (MAGEA11, MAGE11)
Function:
- acts as androgen receptor co-regulator that increases androgen receptor activity by modulating the receptors interdomain interaction
- may play a role in embryonal development, tumor transformation or aspects of tumor progression
Structure: contains 1 MAGE domain
Compartment: nucleus, cytoplasm
Alternative splicing: named isoforms=2
Expression:
- expressed in tumors of several types, including melanoma, head & neck squamous cell carcinoma, lung carcinoma & breast carcinoma
- expressed in testis, ovary, prostate, cancerous prostate, breast & adrenal tissue
General
melanoma associated antigen (MAGE)
nuclear protein
phosphoprotein
Properties
SIZE: entity length = 429 aa
MW = 48 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: Ser phosphorylation site {S76}
melanoma-associated antigen (MAGE) domain {222-421}
Database Correlations
OMIM 300344
UniProt P43364
Pfam PF01454
Entrez Gene 4110
Kegg hsa:4110
References
- UniProt :accession P43364
- Entrez Gene :accession 4110