melanocortin receptor 5; MC5-R; MC-2 (MC5R)

Function: - receptor for MSH-alpha, MSH-beta & MSH-gamma & ACTH - activity is mediated by G proteins which activate adenylate cyclase - possible mediator of the immunomodulation properties of melanocortins Structure: belongs to the G-protein coupled receptor 1 family Compartment: cell membrane Expression: expressed in the brain Pathology: not expressed in melanoma cells

General

glycoprotein melanocortin receptor

Properties

SIZE: entity length = 325 aa MW = 37 kD COMPARTMENT: cellular membrane MOTIF: exoplasmic domain {1-37} MOTIF: N-glycosylation site {N2} N-glycosylation site {N15} N-glycosylation site {N20} N-glycosylation site {N28} transmembrane domain {38-61} cytoplasmic loop {62-73} transmembrane domain {74-97} exoplasmic loop {98-114} transmembrane domain {115-138} cytoplasmic loop {139-155} transmembrane domain {156-179} exoplasmic loop {180-186} transmembrane domain {187-211} cytoplasmic loop {212-239} transmembrane domain {240-265} exoplasmic loop {266-273} transmembrane domain {274-297} cytoplasmic domain {298-325} MOTIF: cysteine residue {C311} MODIFICATION: palmitate COMPARTMENT: membrane cysteine residue {C312} MODIFICATION: palmitate COMPARTMENT: membrane

Database Correlations

OMIM 600042 UniProt P33032 Pfam PF00001 Entrez Gene 4161 Kegg hsa:4161