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melanocortin receptor 3; MC3-R (MC3R)
Function:
- receptor for MSH-alpha, MSH-beta & MSH-gamma & ACTH
- linked to G proteins which activate adenylate cyclase
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane
Expression: brain, placental, & gut tissues
General
glycoprotein
melanocortin receptor
Properties
SIZE: entity length = 360 aa
MW = 40 kD
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-74}
MOTIF: N-glycosylation site {N39}
N-glycosylation site {N53}
N-glycosylation site {N65}
transmembrane domain {75-100}
cytoplasmic loop {101-112}
transmembrane domain {113-137}
exoplasmic loop {138-155}
transmembrane domain {156-177}
cytoplasmic loop {178-197}
transmembrane domain {198-218}
exoplasmic loop {219-223}
transmembrane domain {224-247}
cytoplasmic loop {248-282}
transmembrane domain {283-305}
exoplasmic loop {306-314}
transmembrane domain {315-338}
cytoplasmic domain {339-360}
MOTIF: cysteine residue {C352}
MODIFICATION: palmitate
COMPARTMENT: membrane
Database Correlations
OMIM 155540
MORBIDMAP 155540
UniProt P41968
Pfam PF00001
Entrez Gene 4159
Kegg hsa:4159
References
UniProt :accession P41968