melanin-concentrating hormone receptor 2 (MCH receptor 2, MCHR-2, MCH-R2, MCH2R, MCH-2R, MCH2, G protein coupled receptor 145, GPRv17, GPR145, MCHR2, SLT)

Function: - receptor for melanin-concentrating hormone - coupled to G proteins that activate phosphoinositide hydrolysis Structure: belongs to the G-protein coupled receptor 1 family Compartment: cell membrane Expression: - specifically expressed in the brain - highest levels in cerebral cortex, hippocampus & amygdala - no expression detected in the cerebellum, thalamus or hypothalamus

General

glycoprotein G-protein coupled receptor; serpentine receptor

Properties

SIZE: MW = 39 kD entity length = 340 aa COMPARTMENT: cellular membrane MOTIF: exoplasmic domain {1-39} MOTIF: N-glycosylation site {N10} N-glycosylation site {N17} transmembrane domain {40-60} cytoplasmic loop {61-69} transmembrane domain {70-90} exoplasmic loop {91-104} transmembrane domain {105-129} cytoplasmic loop {130-154} transmembrane domain {155-175} exoplasmic loop {176-200} transmembrane domain {201-221} cytoplasmic loop {222-252} transmembrane domain {253-273} exoplasmic loop {274-288} transmembrane domain {289-309} cytoplasmic domain {310-340}

Database Correlations

OMIM 606111 UniProt Q969V1 Pfam PF00001 Kegg hsa:8453

References

UniProt :accession Q969V1