meiotic recombination protein SPO11 (SPO11)

Function: 1) required for meiotic recombination 2) mediates DNA cleavage that forms double-strand breaks that initiate meiotic recombination Structure: belongs to the TOP6A family Compartment: nucleus Alternative splicing: named isoforms=2 Expression: highly expressed in testis

General

endodeoxyribonuclease nuclear protein

Properties

SIZE: MW = 45 kD entity length = 396 aa COMPARTMENT: cell nucleus MOTIF: tyrosine residue {Y138}

Database Correlations

OMIM 605114 UniProt Q9Y5K1 PFAM correlations

References

UniProt :accession Q9Y5K1