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medications contraindicated during pregnancy
Medications labeled pregnancy category X
- retinoids
a) 13-cis retinoic acid (isotretinoin)*
b) all-trans retinoic acid
c) etretinate (Tegison)
d) tazarotene (Tazorac)
e) acitretin (Soriatane)
- estrogens
a) estradiol
b) clomiphene (Clomid)
c) dienestrol (Cycladiene)
- androgens
a) testosterone
b) methyltestosterone
c) danazol (Danocrine)
d) fluoxymesterone (Haloestin, Ora-Testryl)
e) nandrolone (Durabolin)
f) oxandrolone (Oxandrin)
g) stanozolol
- progestational agents
a) progesterone
b) medroxyprogesterone actetate (Provera)
c) norethindrone (Norlutate)
d) megestrol (Megace)
e) norgestrel (Ovrette)
f) levonorgestrel (Norplant
- gonadotropin-releasing hormone agonists
a) goserelin (Zoladex)
b) leuprolide (Lupron)
c) nafarelin (Synarel)
- gonadotropin analogs
- urofollitropin (FSH-beta)
- finasteride (Proscar)
- nicotine
- fluorescein
- ergot alkaloids
a) dihydroergotamine
b) methysergide (Sansert)
- warfarin*
- exception is mechanical heart valve [1]
- antineoplastic agents
a) 5-fluorouracil (Efudex, 5-FU)
b) methotrexate (X)
c) mechlorethamine (Mustargen, nitrogen mustard)
d) mitomycin C (Mutamycin)
e) streptozocin (Zanosar)
f) thalidomide*
g) flutamide
- disease-modifying antirheumatic agents
- mycophenolate (D)
- leflunomide (X)
- cyclophosphamide (D)
- benzodiazepines
a) estazolam (ProSom)
b) flurazepam (Dalmane)
c) temazepam (Restoril)
d) triazolam (Halcion)
e) quazepam (Doral)
- statins
a) fluvastatin (Lescol)
b) lovastatin (Mevacor)
c) pravastatin (Pravachol)
d) simvastatin (Zocor)
e) atorvastatin (Lipitor)
f) rosuvastatin (Crestor)
g) cerivastatin (Baycol)
- antivrals
a) ribavirin (Virazole)
b) podophyllin (Podofin)
- prostaglandin analogs
a) misoprostol (Cytotec)
b) alprostadil (Muse)
- amyl nitrite
- combinations
a) Bellergal-S or Spastrin (belladonna, phenobarbital, ergotamine)
b) conjugated estrogens (Premarin)
Management:
- mandatory pregnancy prevention program for drugs with *
Related
pregnancy (gestation)
pregnancy category
General
medication
References
- Medical Knowledge Self Assessment Program (MKSAP) 15, 16. 18.
American College of Physicians, Philadelphia 2009, 2012, 2018