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mediator of RNA polymerase 2 transcription subunit 28; endothelial-derived protein 1; mediator complex subunit 28; Merlin & Grb2-interacting cytoskeletal protein; Magicin; tumor angiogenesis marker EG-1 (MED28, EG1, FKSG20)
Function:
- component of mediator complexes
a) MED8 mediator complex
b) IXL mediator complex
- may be part of a complex containing NF2/Merlin that participates in cellular signaling to the actin cytoskeleton downstream of tyrosine kinase signaling pathways
- forms a ternary complex with NF2/Merlin & GRB2
- binds to actin
Structure: belongs to the mediator complex subunit 28 family
Compartment:
- nucleus, cytoplasm
- membrane, peripheral membrane
- cytoplasmic & mainly membrane-associated (some uncertainty)
Expression:
- widely expressed
- highly expressed in vascular tissues such as placenta, testis & liver
- up-regulated by endothelial cells when exposed to tumor conditional media
General
membrane protein
nuclear protein
Properties
SIZE: MW = 20 kD
entity length = 178 aa
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: coiled coil {109-145}
Database Correlations
UniProt Q9H204
Entrez Gene 80306
References
- UniProt :accession Q9H204
- Wiederhold et al. Oncogene 23(54):8815-25. 2004
PMID: 15467741
Component-of
IXL mediator complex (mediator of RNA polymerase 2 transcription)