mediator of RNA polymerase 2 transcription subunit 25 (mediator complex subunit 25, activator-recruited cofactor 92 kD component, ARC92, activator interaction domain 1 protein, p78, MED25, ACID,1 ARC92, PTOV2, TCBAP0758)

Function: - component of the mediator complex - interacts with CREBBP. - interacts with ESR1, GR, RARA, RXRA & THRB (ligand-dependent) - binds the Herpes simplex virus activator VP16 Structure: belongs to the mediator complex subunit 25 family Compartment: nucleus Alternative splicing: named isoforms=5 Expression: - ubiquitously expressed - highest levels in brain, heart, kidney, peripheral leukocytes, placenta, skeletal muscle & spleen

Properties

SIZE: entity length = 747 aa MW = 78 kD COMPARTMENT: cell nucleus MOTIF: mediator complex interaction {1-226} proline-rich region SITE: 200-381 MOTIF: proline residue (SEVERAL) VP16 interaction {389-543} CREBBP interaction {395-545} RARA interaction {564-653} proline-rich region SITE: 565-735 MOTIF: proline residue (SEVERAL) RARA interaction {640-707} LXXLL {646-650}

References

UniProt :accession Q71SY5