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measles virus vaccine, live, attenuated (Attenuvax)

Indications: - immunization against measles (rubeola) in patients > 15 months of age Epidemiology: - small decline in vaccination rate could triple number of measles cases [3] Contraindications: 1) hypersensitivity to eggs 2) hypersensitivity to neomycin 2) pregnancy Caution: 1) history of febrile seizures 2) females should avoid pregnancy for 3 months afer vaccination 3) defer vaccination for 3 months following plasma transfusions or administration of immune globulin or immunosuppressive drugs Dosage: Children > 15 months & adults: 0.5 mL SC Injection: 1000 TCID50 per dose Adverse effects: 1) common (> 10%) a) fever < 100 F b) burning at site of injection 2) less common (1-10%) - fever 100-103 F, delayed-type allergic reaction 3) uncommon (< 1%) - difficulty breathing, hives, itching, reddening of skin (especially around eyes & ears), tiredness, convulsions, encephalitis, confusion, severe headache, stiff neck, vomiting, diplopia, thrombocytopenic purpura, prolonged fever > 103 F, lymphadenopathy 4) risk of fever & seizures greater at age 16-18 months than at 12-15 months [2] Drug interations: Vaccine interactions: - should not be given within 1 month of other live virus vaccines except monovalent or trivalent polio vaccine Test interactions: - temporary suppression of TB skin test reactivity

Related

measles & rubella combined vaccine (M-R-VAX II) measles (1st disease) measles virus (rubeola) measles, mumps & rubella combined vaccine (MMR)

General

live virus vaccine

References

  1. Kaiser Permanente Northern California Regional Drug Formulary, 1998
  2. Rowhani-Rahbar A et al. Effect of age on the risk of fever and seizures following immunization with measles-containing vaccines in children. JAMA Pediatr 2013 Oct 14 PMID: 24126936 http://archpedi.jamanetwork.com/article.aspx?articleid=1750204 - Feemster KA and Offit P. Delaying vaccination is not a safer choice. JAMA Pediatr 2013 Oct 14 PMID: 24126848 http://archpedi.jamanetwork.com/article.aspx?articleid=1750202
  3. Lo NC, Hotez PJ Public Health and Economic Consequences of Vaccine Hesitancy for Measles in the United States. JAMA Pediatr. Published online July 24, 2017 PMID: 28738137 http://jamanetwork.com/journals/jamapediatrics/fullarticle/2643169

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measles virus vaccine live attenuated/mumps virus vaccine/rubella virus vaccine live measles virus vaccine live attenuated/mumps virus vaccine/rubella virus vaccine live/varicella virus vaccine measles virus vaccine live attenuated/rubella virus vaccine live