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Mdm4 protein; Mdm2-like p53-binding protein; Mdmx protein; double minute 4 protein (MDM4, MDMX)
Function:
- inhibits p53- & p73-mediated cell cycle arrest & apoptosis by binding its transcriptional activation domain
- inhibits degradation of MDM2
- can reverse MDM2-targeted degradation of p53 while maintaining suppression of p53 transactivation & apoptotic functions
- binds to p53, p73 & MDM2
Structure:
- region I
a) sufficient for binding p53 & inhibiting its G1 arrest & apoptosis function
b) also binds p73
- region II
a) contains most of a central acidic region
b) contains a putative C4-type Zn+2 finger
- RING finger domain
a) coordinates 2 Zn+2
b) mediates the heterooligomerization with MDM2
- belongs to the MDM2/MDM4 family
- contains 1 RanBP2-type Zn+2 finger
- contains 1 RING-type Zn+2 finger
- contains 1 SWIB domain
- mass spec: mass=54863.3; method=MALDI; Range=1-490
Compartment: nucleus
Expression:
- expressed all tissues tested
- high levels in thymus
Interactions
molecular events
General
nuclear protein
Properties
SIZE: entity length = 490 aa
MW = 55 kD
COMPARTMENT: cell nucleus
MOTIF: SWIB {26-106}
acidic region {243-308}
MOTIF: acidic residue (SEVERAL)
Region II {246-332}
MOTIF: Zinc finger
NAME: Zinc finger
SITE: 300-329
EFFECTOR-BOUND: Zn+2
RING-finger {437-478}
MOTIF: nuclear translocation signal {442-445}
EFFECTOR-BOUND: Zn+2
FOR-BINDING-OF: DNA motif
Database Correlations
OMIM 602704
UniProt O15151
Pfam PF02201
Entrez Gene 4194
Kegg hsa:4194
References
- Entrez Gene :accession 4194
- UniProt :accession O15151
Component-of
molecular complex