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mdm2 proto-oncogene

Gene amplified in 17 of 47 sarcomas. In addition to p53, MDM2 gene is also regulated by the Ras/Raf/MEK/MAP kinase pathway through activation of Ets & AP-1 sites in the P2 promoter upstream from & independent of the p53 response element [3]

Related

E3 ubiquitin-protein ligase Mdm2; p53-binding protein Mdm2; oncoprotein Mdm2; double minute 2 protein; Hdm2 (MDM2)

General

proto-oncogene

Properties

TEMPLATE-FOR: messenger RNA TEMPLATE-FOR: E3 ubiquitin-protein ligase Mdm2 LOCUS: human chromosome-12 Q13-14 MOTIF: p53-response element transcriptional start site exon intron transcriptional termination site

References

  1. Oliner JD, Kinzler KW, Meltzer PS, George DL, Vogelstein B. Amplification of a gene encoding a p53-associated protein in human sarcomas. Nature. 1992 Jul 2;358(6381):80-3. PMID: 1614537
  2. Lane DP. Cancer. p53, guardian of the genome. Nature. 1992 Jul 2;358(6381):15-6. PMID: 1614522
  3. Ries S, Biederer C, Woods D, Shifman O, Shirasawa S, Sasazuki T, McMahon M, Oren M, McCormick F. Opposing effects of Ras on p53: transcriptional activation of mdm2 and induction of p19ARF. Cell. 2000 Oct 13;103(2):321-30. PMID: 11057904