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Max-like protein X (Max-like bHLHZip protein, BigMax protein, protein Mlx, transcription factor-like protein 4, MLX, TCFL4)
Function:
- transcription regulator
- forms a sequence-specific DNA-binding protein complexes with MAD1, MAD4, MNT & WBSCR14 which recognizes the core sequence 5'-CACGTG-3'
- the TCFL4-MAD1, TCFL4-MAD4, TCFL4-WBSCR14 complexes are transcriptional repressors.
- efficient DNA binding requires dimerization with another bHLH protein
- binds DNA as a heterodimer with MAD1, MAD4, MNT & WBSCR14
- can also bind DNA as a homodimer
Structure:
- contains 1 basic helix-loop-helix (bHLH) domain
Compartment:
- isoforms alpha & beta: cytoplasm
- isoform gamma: nucleus
Alternative splicing: named isoforms=3
Expression:
- expressed in all tissues tested, including spleen, thymus, prostate, ovary, intestine, colon, peripheral blood leukocyte, heart, liver, skeletal muscle & kidney
- lower levels of expression in testis, brain, placenta, lung
General
DNA-binding protein
Properties
SIZE: MW = 33 kD
entity length = 298 aa
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: DNA-binding motif
SITE: 76-87
helix-loop-helix
NAME: helix-loop-helix
SITE: 91-134
FOR-BINDING-VIA: helix-loop-helix
leucine zipper
SITE: 140-160
FOR-BINDING-VIA: leucine zipper
Database Correlations
OMIM 602976
UniProt Q9UH92
Pfam PF00010
References
UniProt :accession Q9UH92