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Max dimerization protein 4; Max dimerizer 4; class C basic helix-loop-helix protein 12; bHLHc12; Max-associated protein 4; Max-interacting transcriptional repressor MAD4 (MXD4, BHLHC12, MAD4)
Function:
- transcriptional repressor
- binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'
- antagonizes MYC transcriptional activity by competing for MAX & suppresses MYC dependent cell transformation (putative)
- efficient DNA binding requires dimerization with another bHLH protein
- binds DNA as a heterodimer with MAX
- interacts with SIN3A AND SIN3B
- interacts with RNF17 (putative)
Structure:
- contains 1 basic helix-loop-helix (bHLH) domain
Compartment: nucleus (putative)
Related
MAX-associated protein; MAX dimerizing protein
General
transcriptional silencer (transcriptional repressor)
Properties
SIZE: entity length = 209 aa
MW = 24 kD
COMPARTMENT: cell nucleus
MOTIF: SIN3A and SIN3B interaction {6-23}
DNA-binding motif
SITE: 55-66
helix-loop-helix
NAME: helix-loop-helix
SITE: 67-106
FOR-BINDING-VIA: helix-loop-helix
Database Correlations
UniProt Q14582
Pfam PF00010
Entrez Gene 10608
Kegg hsa:10608
References
UniProt :accession Q14582