Max-interacting transcriptional repressor MAD3 (Max-associated protein 3, MAX dimerization protein 3, Myx, MXD3, MAD3)

Function: - transcriptional repressor - binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3' - antagonizes MYC transcriptional activity by competing for MAX - suppresses MYC dependent cell transformation - efficient DNA binding requires dimerization with another bHLH protein - binds DNA as a heterodimer with MAX - interacts with SIN3A & SIN3B Structure: contains 1 basic helix-loop-helix domain (bHLH) Compartment: nucleus Alternative splicing: named isoforms=3

General

basic helix loop helix (bHLH) family transcription factor transcriptional silencer (transcriptional repressor)

Properties

SIZE: MW = 23 kD entity length = 206 aa COMPARTMENT: cell nucleus MOTIF: interaction with SIN3A & SIN3B {8-25} DNA-binding motif SITE: 59-70 helix-loop-helix NAME: helix-loop-helix SITE: 71-110 FOR-BINDING-VIA: helix-loop-helix

Database Correlations

UniProt Q9BW11 Pfam PF00010

References

UniProt :accession Q9BW11