Contents

Search

MAX-interacting protein 1; protein MXI1 (MXI1)

Function: - transcriptional repressor - MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3' - MXI1 thus antagonizes MYC - transcriptional activity by competing for MAX - interacts with SMC3 (putative) - efficient DNA binding requires dimerization with another bHLH protein - binds DNA as a heterodimer with MAX - interacts with RNF17 (putative) Structure: contains 1 basic helix-loop-helix (bHLH) domain Compartment: nucleus Alternative splicing: named isoforms=2 Expression: - expressed brain, heart & lung > liver, kidney & skeletal muscle Pathology: - defects in MXI1 are found in some patients with prostate cancer (CaP)

Interactions

molecular events

Related

mxi1 gene

General

basic helix loop helix (bHLH) family transcription factor

Properties

SIZE: entity length = 220 aa COMPARTMENT: cell nucleus MOTIF: basic helix-loop-helix {32-83} MOTIF: basic DNA-binding motif helix-loop-helix NAME: helix-loop-helix FOR-BINDING-VIA: helix-loop-helix FOR-BINDING-OF: DNA motif FOR-BINDING-VIA: helix-loop-helix leucine zipper SITE: 84-112 FOR-BINDING-VIA: leucine zipper

Database Correlations

OMIM correlations UniProt P50539 Pfam PF00010 Entrez Gene 4601

References

  1. Zervos AS, Gyuris J, Brent R. Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites. Cell. 1993 Jan 29;72(2):223-32. Erratum in: Cell. 1994 Oct 21;79(2):following 388. PMID: 8425219 (correction Cell 79:388 1994)
  2. Entrez Gene :accession 4601
  3. Atlas of genetics & cytogenetics in oncology & haematology http://atlasgeneticsoncology.org/genes/MXI1ID209.html
  4. UniProt :accession P50539

Component-of

molecular complex