MAX gene-associated protein (MGA KIAA0518)

Function: - dual-specificity transcription factor - regulaties expression of both MAX-network & T-box family target genes - functions as a repressor or an activator - binds to 5'-AATTTCACACCTAGGTGTGAAATT-3' core sequence & seems to regulate MYC-MAX target genes - suppresses transcriptional activation by MYC & inhibits MYC-dependent cell transformation - function activated by heterodimerization with MAX - heterodimerization serves the dual function of both generating an E-box-binding heterodimer & simultaneously blocking interaction of a corepressor - interacts with MAX - requires dimerization with MAX for E-box binding (putative) Structure: - transcription repression is enhanced or dependent on the presence of the T-box DNA-binding domain (putative) - contains 1 basic helix-loop-helix (bHLH) domain - contains 1 T-box DNA-binding domain Compartment: nucleus (probable) Alternative splicing: named isoforms=2

General

DNA-binding protein phosphoprotein

Properties

SIZE: entity length = 3026 aa MW = 332 kD COMPARTMENT: cell nucleus MOTIF: T-box domain SITE: 84-260 glutamine-rich region {967-981} MOTIF: glutamine residue (SEVERAL) coiled coil {1111-1147} serine-rich region {1255-1263} MOTIF: serine residue (SEVERAL) threonine-rich region {1594-1714} MOTIF: threonine residue (SEVERAL) DNA-binding motif SITE: 1876-2383 MOTIF: Ser phosphorylation site {S1973} helix-loop-helix NAME: helix-loop-helix SITE: 2384-2436 FOR-BINDING-VIA: helix-loop-helix coiled coil {2778-2802}

Database Correlations

UniProt Q8IWI9 Pfam PF00907

References

UniProt :accession Q8IWI9