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matrix metalloproteinase-26; matrixin 26; matrilysin-2; endometase (MMP26)
Function:
- may hydrolyze collagen type 4, fibronectin, fibrinogen, beta-casein, gelatin type 1 & alpha-1 proteinase inhibitor
- also able to activate progelatinase B
Cofactor:
- binds 1 Zn+2 per subunit (putative)
- Ca+2 (putative)
Structure:
- the conserved Cys present in the cysteine-switch motif binds the catalytic Zn+2, thus inhibiting the enzyme
- dissociation of Cys from Zn+2 upon activation- peptide release activates the enzyme
- belongs to the peptidase M10A family
Compartment:
- secreted, extracellular space, extracellular matrix
Expression:
- expressed specifically in uterus & placenta
Pathology:
- widely expressed in malignant tumors from different sources as well as in diverse tumor cell lines
General
matrixin or matrix metalloproteinase
Properties
SIZE: entity length = 261 aa
MW = 30 kD
COMPARTMENT: extracellular matrix
MOTIF: signal sequence {1-17}
N-glycosylation site {N64}
Cysteine switch {80-87}
MOTIF: Zn+2-binding site
SITE: 82-82
Zn+2-binding site
SITE: 208-208
glutamate residue {E209}
Zn+2-binding site
SITE: 212-212
Zn+2-binding site
SITE: 218-218
N-glycosylation site {N221}
Database Correlations
OMIM 605470
UniProt Q9NRE1
Pfam PF00413
Entrez Gene 56547
Kegg hsa:56547
References
UniProt :accession Q9NRE1