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matrix Gla protein; MGP; cell growth-inhibiting gene 36 protein (MGP, MGLAP, GIG36)
Function:
- associates with the organic matrix of bone & cartilage
- thought to act as an inhibitor of bone formation
- requires vitamin K-dependent gamma-carboxylation for its function
Structure:
- belongs to the osteocalcin/matrix Gla protein family
- contains 1 Gla (gamma-carboxy-glutamate) domain
Compartment: secreted
Pathology:
- defects in MGP are the cause of Keutel syndrome
General
matrix protein
phosphoprotein
Properties
SIZE: entity length = 103 aa
MW = 12 kD
COMPARTMENT: extracellular matrix
MOTIF: signal sequence {1-19}
Ser phosphorylation site {S22}
Ser phosphorylation site {S25}
Ser phosphorylation site {S28}
Gla {51-97}
MOTIF: cysteine residue {C73}
MODIFICATION: cysteine residue {C79}
cysteine residue {C79}
MODIFICATION: cysteine residue {C73}
Database Correlations
OMIM correlations
UniProt P08493
Pfam PF00594
Entrez Gene 4256
Kegg hsa:4256
References
- UniProt :accession P08493
- SeattleSNPs
http://pga.gs.washington.edu/data/mgp/