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matrix metalloproteinase-8 (matrixin-8, neutrophil collagenase, PMNL collagenase, PMNL-CL, MMP8, CLG1)
Function:
- can degrade fibrillar collagens type 1, 2, & 3
- cannot be activated without removal of the activation peptide
- cleavage of interstitial collagens in the triple helical domain
- cleaves collagen type 3 more slowly than collagen type 1
Cofactor:
- binds 3 Ca+2 per subunit
- binds 2 Zn+2 per subunit
Structure:
- conserved Cys present in the cysteine-switch motif binds the catalytic Zn+2, thus inhibiting the enzyme; dissociation of the Cys from the Zn+2 upon the activation-peptide release activates the enzyme
- belongs to the peptidase M10A family
- contains 4 hemopexin-like domains
Compartment:
- cytoplasmic granule
- stored in intracellular granules
Expression: neutrophils
General
collagenase
matrixin or matrix metalloproteinase
Properties
SIZE: entity length = 467 aa
MW = 53 kD
COMPARTMENT: cytoplasm
MOTIF: signal sequence {1-20}
N-glycosylation site {N54}
N-glycosylation site {N73}
Cysteine switch {89-96}
MOTIF: Zn+2-binding site
SITE: 91-91
N-glycosylation site {N112}
Ca+2-binding site
SITE: 157-157
Zn+2-binding site
SITE: 167-167
Zn+2-binding site
SITE: 169-169
Ca+2-binding site
SITE: 174-174
Ca+2-binding site
SITE: 175-175
Ca+2-binding site
SITE: 177-177
Ca+2-binding site
SITE: 179-179
Zn+2-binding site
SITE: 182-182
Ca+2-binding site
SITE: 189-189
Ca+2-binding site
SITE: 191-191
Ca+2-binding site
SITE: 193-193
Zn+2-binding site
SITE: 195-195
Ca+2-binding site
SITE: 197-197
Ca+2-binding site
SITE: 200-200
N-glycosylation site {N204}
Zn+2-binding site
SITE: 217-217
glutamate residue {E218}
Zn+2-binding site
SITE: 221-221
Zn+2-binding site
SITE: 227-227
N-glycosylation site {N246}
cysteine residue {C279}
MODIFICATION: cysteine residue {C464}
Hemopexin-like 1 {285-327}
MOTIF: Ca+2-binding site
SITE: 286-286
Hemopexin-like 2 {329-372}
Hemopexin-like 3 {377-422}
MOTIF: Ca+2-binding site
SITE: 378-378
Hemopexin-like 4 {424-464}
MOTIF: Ca+2-binding site
SITE: 425-425
cysteine residue {C464}
MODIFICATION: cysteine residue {C279}
Database Correlations
OMIM 120355
UniProt P22894
PFAM correlations
Entrez Gene 4317
Kegg hsa:4317
ENZYME 3.4.24.34
References
UniProt :accession P22894