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matrixin or matrix metalloproteinase

family of extracellular soluble or membrane bound proteases Function: 1) involved in a) remodelling of extracellular matrix b) regulation of inflammatory and repair processes. 2) substrates include: a) structural proteins b) proteases c) clotting factors d) growth factors e) chemokines f) cell surface receptors g) adhesion molecules Expression: - expressed in many cells including macrophages, fibroblasts, endothelial cells & most cancer cells

Specific

matrix metalloproteinase-1; matrixin-1; interstitial collagenase; fibroblast collagenase (MMP1, CLG) matrix metalloproteinase-2 (matrixin-2, TBE-1, 72 kD gelatinase, gelatinase A, MMP2, CLG4A) matrix metalloproteinase-3 (matrixin-3, stromelysin-1, transin-1, SL-1, MMP3, STMY1) matrix metalloproteinase-7 (matrixin-7, matrin, urine metalloproteinase, pump-1 protease, matrylisin, MMP7, MPSL1, PUMP1) matrix metalloproteinase-8 (matrixin-8, neutrophil collagenase, PMNL collagenase, PMNL-CL, MMP8, CLG1) matrix metalloproteinase-9 (matrixin-9, 92 kD gelatinase, gelatinase-B, MMP9, CLG4B) matrix metalloproteinase-10 (matrixin-10, stromelysin-2, transin-2, MMP10, STMY2) matrix metalloproteinase-11 (matrixin-11, stromelysin-3, transin-3, MMP11, STMY3) matrix metalloproteinase-12 (matrixin-12, macrophage metalloelastase, MMP12, HME) matrix metalloproteinase-13 (matrixin-13, collagenase-3, MMP13) matrix metalloproteinase-14 (matrixin-14, membrane-type matrix metalloproteinase 1, MMP14, MTMMP1, MT1MMP, MMP- X1, MT1-MMP) matrix metalloproteinase-15 (matrixin-15, membrane-type matrix metalloproteinase 2, MTMMP2, MMP15, MT2MMP, SMCP-2) matrix metalloproteinase-16 (matrixin-16, membrane-type matrix metalloproteinase 3, MTMMP3, MMPX2 MMP16) matrix metalloproteinase-17; matrixin 17; MMP-17; membrane-type matrix metalloproteinase 4; MT-MMP 4; membrane-type-4 matrix metalloproteinase; MT4-MMP; Puente (MMP17, MT4MMP) matrix metalloproteinase-19; MMP-19; matrix metalloproteinase RASI; MMP-18 (MMP19, MMP18, RASI) matrix metalloproteinase-20; matrixin 20; enamel metalloproteinase; enamelysin (MMP20) matrix metalloproteinase-21; matrixin 21 (MMP21) matrix metalloproteinase-23; MMP-23; matrix metallopeptidase 21; MMP-21; matrix metalloprotease 22; MMP-22; femalysin; MIFR-1 (MMP23A, MMP23B, MMP22) matrix metalloproteinase-24; MMP-24; membrane-type matrix metalloproteinase 5; MT-MMP 5;membrane-type-5 matrix metalloproteinase; MT5-MMP (MMP24, MT5MMP) matrix metalloproteinase-25; matrixin 25; membrane-type matrix metalloproteinase 6; leukolysin; membrane-type-6 matrix metalloproteinase; MT6-MMP (MMP25, MMPL1, MT6MMP) matrix metalloproteinase-26; matrixin 26; matrilysin-2; endometase (MMP26) matrix metalloproteinase-27; matrixin 27 (MMP27) matrix metalloproteinase-28; matrixin 28; epilysin (MMP28, UNQ1893/PRO4339)

General

secreted protein zinc metalloprotease

Properties

COMPARTMENT: extracellular matrix MOTIF: active site MOTIF: Zn+2-binding site EFFECTOR-BOUND: Zn+2 MOTIF: histidine residue (2) glutamate residue cysteine switch SITE: C-TERMINAL FOR-BINDING-OF: Zn+2 MOTIF: cysteine residue

References

  1. Conference Report - Extracellular Matrix and Cancer: Revisiting Metalloproteinases http://www.medscape.com/viewarticle/467812_3
  2. Parks et al. Nature Reviews Immunology 4:617-629, 2004 PMID: 15286728