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suppressor of tumorigenicity 14 protein; matriptase; membrane-type serine protease 1; MT-SP1; prostamin; serine protease 14; serine protease TADG-15; tumor-associated differentially-expressed gene 15 protein (ST14, PRSS14, SNC19, TADG15)
Function:
- degrades extracellular matrix
- has trypsin-like activity
- cleaves synthetic substrates with Arg or Lys at the P1 position
- prefers small side-chain amino acids, such as Ala & Gly, at the P2 position
- interacts with CDCP1
- may interact with TMEFF1
Structure:
- belongs to the peptidase S1 family
- contains 2 CUB domains
- contains 4 LDL-receptor class A domains
- contains 1 peptidase S1 domain
Compartment:
- membrane
- single-pass type 2 membrane protein (probable)
Pathology:
- defects in ST14 are a cause of ichthyosis autosomal recessive with hypotrichosis
- may play a role in breast cancer invasion & metastasis
General
anti-oncoprotein (tumor suppressor protein)
glycoprotein
membrane protein
serine protease
Properties
SIZE: entity length = 855 aa
MW = 95 kD
COMPARTMENT: cellular membrane
MOTIF: transmembrane domain {56-76}
N-glycosylation site {N109}
CUB domain {214-334}
MOTIF: cysteine residue {C214}
MODIFICATION: cysteine residue {C244}
cysteine residue {C244}
MODIFICATION: cysteine residue {C214}
N-glycosylation site {N302}
CUB domain {340-447}
MOTIF: cysteine residue {C340}
MODIFICATION: cysteine residue {C366}
cysteine residue {C366}
MODIFICATION: cysteine residue {C340}
cysteine residue {C397}
MODIFICATION: cysteine residue {C410}
cysteine residue {C410}
MODIFICATION: cysteine residue {C397}
LDL-receptor class A {452-487}
MOTIF: cysteine residue {C453}
MODIFICATION: cysteine residue {C464}
cysteine residue {C459}
MODIFICATION: cysteine residue {C477}
cysteine residue {C464}
MODIFICATION: cysteine residue {C453}
cysteine residue {C471}
MODIFICATION: cysteine residue {C486}
cysteine residue {C477}
MODIFICATION: cysteine residue {C459}
N-glycosylation site {N485}
cysteine residue {C486}
MODIFICATION: cysteine residue {C471}
LDL-receptor class A {487-524}
MOTIF: cysteine residue {C488}
MODIFICATION: cysteine residue {C501}
cysteine residue {C496}
MODIFICATION: cysteine residue {C514}
cysteine residue {C501}
MODIFICATION: cysteine residue {C488}
cysteine residue {C508}
MODIFICATION: cysteine residue {C523}
cysteine residue {C514}
MODIFICATION: cysteine residue {C496}
cysteine residue {C523}
MODIFICATION: cysteine residue {C508}
LDL-receptor class A {524-560}
MOTIF: cysteine residue {C525}
MODIFICATION: cysteine residue {C537}
cysteine residue {C532}
MODIFICATION: cysteine residue {C550}
cysteine residue {C537}
MODIFICATION: cysteine residue {C525}
cysteine residue {C544}
MODIFICATION: cysteine residue {C559}
cysteine residue {C550}
MODIFICATION: cysteine residue {C532}
cysteine residue {C559}
MODIFICATION: cysteine residue {C544}
LDL-receptor class A {566-603}
MOTIF: cysteine residue {C567}
MODIFICATION: cysteine residue {C579}
cysteine residue {C574}
MODIFICATION: cysteine residue {C593}
cysteine residue {C579}
MODIFICATION: cysteine residue {C567}
cysteine residue {C587}
MODIFICATION: cysteine residue {C602}
cysteine residue {C593}
MODIFICATION: cysteine residue {C574}
cysteine residue {C602}
MODIFICATION: cysteine residue {C587}
S1 domain {615-854}
MOTIF: cysteine residue {C641}
MODIFICATION: cysteine residue {C657}
histidine residue {H656}
cysteine residue {C657}
MODIFICATION: cysteine residue {C641}
aspartate residue {D711}
N-glycosylation site {N772}
cysteine residue {C776}
MODIFICATION: cysteine residue {C790}
cysteine residue {C790}
MODIFICATION: cysteine residue {C776}
cysteine residue {C801}
MODIFICATION: cysteine residue {C830}
serine residue {S805}
cysteine residue {C830}
MODIFICATION: cysteine residue {C801}
Database Correlations
OMIM correlations
UniProt Q9Y5Y6
PFAM correlations
Entrez Gene 6768
Kegg hsa:6768
References
UniProt :accession Q9Y5Y6