matrin-3 (MATR3, KIAA0723 matrin)

Function: - may play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network - in association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs - part of complex consisting of SFPQ, NONO & MATR3 Structure: - contains 1 matrin-type Zn⁺² finger - contains 2 RRM domain (RNA recognition motifs) Compartment: nucleus matrix

General

nuclear protein phosphoprotein RNA-binding protein

Properties

SIZE: entity length = 847 aa MW = 95 kD COMPARTMENT: cell nucleus MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl Ser phosphorylation site {S22} Ser phosphorylation site {S118} Ser phosphorylation site {S188} Ser phosphorylation site {S195} Ser phosphorylation site {S206} Ser phosphorylation site {S208} Ser phosphorylation site {S397} RNP motif NAME: RNP motif SITE: 398-473 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif RNP motif NAME: RNP motif SITE: 496-571 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif Ser phosphorylation site {S533} Ser phosphorylation site {S596} Ser phosphorylation site {S598} Ser phosphorylation site {S604} Ser phosphorylation site {S606} Ser phosphorylation site {S654} Ser phosphorylation site {S671} Ser phosphorylation site {S673} Ser phosphorylation site {S674} Ser phosphorylation site {S696} nuclear translocation signal {710-718} Tyr phosphorylation site {Y773} Zn finger matrin-type NAME: Zn finger matrin-type SITE: 801-832 EFFECTOR-BOUND: Zn+2

Database Correlations

OMIM 164015 MORBIDMAP 164015 UniProt P43243 Entrez Gene 9782 Kegg hsa:9782

References

UniProt :accession P43243