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mast cell protease-1; mast cell protease-7; chymase (CMA1, MCP1)
Function:
- major secreted protease of mast cells
- suspected roles in vasoactive peptide generation, extracellular matrix degradation, & regulation of gland secretion
- preferential cleavage: Phe-|-Xaa > Tyr-|-Xaa > Trp-|-Xaa > Leu-|-Xaa
Structure:
- belongs to the peptidase S1 family, Granzyme subfamily
- contains 1 peptidase S1 domain
Compartment:
- secreted, cytoplasmic granul, mast cell granules
Expression: mast cells in lung, heart, skin & placenta
General
secreted protein
serine protease trypsin family
Properties
SIZE: entity length = 247 aa
MW = 27 kD
COMPARTMENT: cytoplasm
MOTIF: signal sequence {1-19}
S1 domain {22-245}
MOTIF: cysteine residue {C51}
MODIFICATION: cysteine residue {C67}
histidine residue {H66}
cysteine residue {C67}
MODIFICATION: cysteine residue {C51}
N-glycosylation site {N80}
N-glycosylation site {N103}
aspartate residue {D110}
cysteine residue {C144}
MODIFICATION: cysteine residue {C209}
cysteine residue {C175}
MODIFICATION: cysteine residue {C188}
cysteine residue {C188}
MODIFICATION: cysteine residue {C175}
serine residue {S203}
cysteine residue {C209}
MODIFICATION: cysteine residue {C144}
Database Correlations
OMIM 118938
UniProt P23946
Pfam PF00089
Kegg hsa:1215
ENZYME 3.4.21.39
References
UniProt :accession P23946