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mastermind-like family protein
Transcriptional coactivators for notch receptors.
Contain N-terminal basic domain which binds the intracellular domain of notch (ICN) & C-terminal transcriptional activation domain.
Specific
mastermind homolog MAML1 (Mastermind-like protein 1, KIAA0200)
mastermind homolog MAML2 (mastermind like 2, Mam-2, MAML2, KIAA1819)
mastermind homolog MAML3 (MAML3, KIAA1816)
General
nuclear protein
Properties
COMPARTMENT: cell nucleus
References
- Wu L et al.
Identification of a family of mastermind-like transcriptional
coactivators for mammalian notch receptors.
Mol Cell Biol 22:7688-700, 2002
PMID: 12370315
- Maillard I & Pear WS.
Notch and cancer: best to avoid the ups and downs.
Cancer Cell 3:203-5, 2003
PMID: 12676578