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mastermind homolog MAML3 (MAML3, KIAA1816)
Function:
1) transcriptional coactivator for NOTCH proteins
2) amplifies NOTCH-induced transcription of HES1
3) interacts through its N-terminal region with ankyrin repeat region of Notch proteins NOTCH1, NOTCH2, NOTCH3 & NOTCH4
4) forms a DNA-binding complex with Notch proteins & RBPSUH/RBP-J kappa
Structure:
- belongs to the mastermind family
- C-terminal domain is required for transcriptional activation
Compartment:
- nucleus, nuclear speckle
General
mastermind-like family protein
Properties
SIZE: MW = 122 kD
entity length = 1133 aa
COMPARTMENT: cell nucleus
MOTIF: glutamine-rich region {467-964}
MOTIF: glutamine residue (SEVERAL)
Database Correlations
OMIM 608991
UniProt Q96JK9
Pfam PF09596
Entrez Gene 55534
Kegg hsa:55534
References
- UniProt :accession Q96JK9
- Wu L et al.
Identification of a family of mastermind-like transcriptional
coactivators for mammalian notch receptors.
Mol Cell Biol 22:7688-700, 2002
PMID: 12370315