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mastermind homolog MAML1 (Mastermind-like protein 1, KIAA0200)
Function:
1) transcriptional coactivator for NOTCH proteins
2) amplifies NOTCH-induced transcription of HES1
3) enhances phosphorylation & proteolytic turnover of NOTCH intracellular domain in the nucleus via interaction with CDK8
4) induces phosphorylation & localization of CREBBP to nuclear foci
5) binds to ankyrin repeat domain of all 4 Notch receptors
6) forms DNA-binding complex with Notch proteins & RBPSUH
7) binds CREBBP, CDK8
Compartment:
- nucleus, nucleoplasm, nuclear speckle
Expression:
- widely expressed
- highest levels in heart, pancreas, peripheral blood leukocytes, spleen
General
mastermind-like family protein
Properties
SIZE: MW = 108 kD
entity length = 1016 aa
COMPARTMENT: cell nucleus
MOTIF: binding site
SITE: 1-123
FOR-BINDING-OF: notch (Drosophila) homolog protein
glutamine-rich region {642-645}
MOTIF: glutamine residue (SEVERAL)
Database Correlations
OMIM 605424
UniProt Q92585
Pfam PF09596
Entrez Gene 9794
Kegg hsa:9794
References
UniProt :accession Q92585