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MAPT (microtubule-associated protein tau) gene
16 exons (exons 0-14 & exon 4a).
Alternative splicing:
- microtubule associated protein tau forms generated by alternative splicing of 11 of 16 exons
- exon 0 is part of the promoter
- exons 9, 10, 11, & 12 encode microtubule-binding domains
- exons 1, 4, 5, 7, 9, 11, 12, & 13 are constitutively expressed
- splicing of exons 2, 3 & 10 produce 6 alternatively spliced forms
- thus 3 or 4 microtubule-binding domains occcur in tau forms depending upon alternative splicing of exon 10
- exons 6 & 8 are not transcribed in human CNS
Related
microtubule-associated protein tau (neurofibrillary tangle protein, paired helical filament-tau, PHF-tau, MAPT, MTBT1, m-tau, mtau)
General
unclassified gene
Properties
TEMPLATE-FOR: messenger RNA
TEMPLATE-FOR: microtubule-associated protein tau
LOCUS: human chromosome-17 Q21.1
MOTIF: transcription factor binding site
transcriptional start site
exon (16)
intron (15)
transcriptional termination site
Database Correlations
OMIM 157140
MORBIDMAP 157140
References
Cairns NJ, Lee VM, Trojanowski JQ.
The cytoskeleton in neurodegenerative diseases.
J Pathol. 2004 Nov;204(4):438-49. Review.
PMID: 15495240