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MAP3K12 binding inhibitory protein 1 (MAPK upstream kinase-binding inhibitory protein, MUK-binding inhibitory protein, MBIP)
Function:
1) inhibits the MAP3K12 activity
2) activation of JNK pathway
Compartment:
- nuclear
- cytoplasmic when co-expressed with MAP3K12
Expression:
- ubiquitous
- high expression in heart, lung
General
nuclear protein
Properties
SIZE: MW = 39 kD
entity length = 344 aa
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: binding site
SITE: 172-344
FOR-BINDING-OF: MAP kinse kinase kinase 12
MOTIF: leucine zipper
SITE: 271-285
FOR-BINDING-VIA: leucine zipper
leucine zipper
SITE: 314-329
FOR-BINDING-VIA: leucine zipper
Database Correlations
UniProt Q9NS73
References
UniProt :accession Q9NS73
Component-of
ADA2A-containing complex